Structure determination by 1H and 13C NMR
Instructor: Jeremy Wulff
Content: This module is intended to provide a practical understanding of the routine NMR techniques used to characterize organic molecules. We will cover almost nothing in the way of theory, but instead will focus on interpretation of 1D and 2D NMR spectra. This module will provide a good introduction for Hof's module NMR Characterization of Dynamic Systems, and Rosenberg's module NMR Theory & Heteronuclear NMR. Spectral techniques to be discussed include:
1. 1D 1H NMR
- chemical shifts for common functional groups
- coupling constants and the deconvolution thereof
- non-first order effects
2. 1D 13C NMR
- chemical shifts for common functional groups
- discussion of proton-coupled and decoupled spectra, DEPT, etc.
3. IR
I know it's not NMR, but we have to talk about it somewhere
- carbonyls, alkynes, allenes, alcohols
4. 2D NMR
- COSY, NOESY, HSQC, HMBC, etc.
Delivery: Twelve 1-hour lectures. Scheduling will be determined by arrangement with those who've signed up. Because much of this material will be familiar to you from undergrad classes (eg 213), I'll probably go fairly quickly through the first couple of sections, in order to leave time for working through problems in class.
Textbook: Spectroscopic Methods in Organic Chemistry, Williams & Fleming. Any edition will do. Plenty of used copies available online if you're broke.
Assessment: Three quizzes, plus a bunch of structure-assignment problems.