Dr. Nicole Templeman
Areas of research focus
- Aging biology
- Nutrient-sensing signaling pathways (e.g., insulin signaling)
- Physiology, cell biology, genetics
In the Templeman lab, the goal of our research program is to better understand the physiological deterioration that characterizes aging, through research projects that span molecular and cellular changes to the whole organism. One of the earliest features of aging is a decline in female reproductive health, which is a major focus of our work. We study signaling pathways and mechanisms that coordinate nutritional status with metabolic processes, reproduction, and the maintenance of cell and tissue integrity with age.
- Biology 365: Animal Physiology
- Biology 432: Molecular Endocrinology
- Templeman, N.M., Cota, V., Keyes, W., Kaletsky, R., and Murphy, C.T. (2020). CREB non-autonomously controls reproductive aging through Hedgehog/Patched signaling. Developmental Cell 54(1): 92-105.
- Templeman, N.M., Luo, S., Kaletsky, R., Shi, C., Ashraf, J., Keyes, W., and Murphy, C.T. (2018). Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity. Current Biology 28(5): 753–760.
- Templeman, N.M., and Murphy, C.T. (2018). Regulation of reproduction and longevity by nutrient-sensing pathways. Journal of Cell Biology 217(1): 93–106.
- Templeman, N.M., Flibotte, S., Chik, J.H.L., Sinha, S., Lim, G.E., Foster, L.J., Nislow, C., and Johnson, J.D. (2017). Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. Cell Reports 20:451–463.